Early Response in Adolescents with Schizophrenia is not Associated with Remission at Six Months

摘要

Objective The objectives of present study were to determine the frequency of early response (ER), defined as a 20% decrease in total baseline PANSS score at three weeks and to compare the rate of symptomatic and functional remission between schizophrenic adolescents with and without ER. Methods The sample included 61 patients (65% males) with a mean age of 15 (+ 1.54) y.o., 88.5% on their first episode of psychosis who were evaluated with PANSS and PSP scales y. They were evaluated with PANSS at week three and with PANSS and PSP at month six. Results Twenty-three patients (37.7%) showed ER. There were no significant differences in the rate of symptomatic or functional remission at month six between responders and non-responders. Conclusions Early response to antipsychotic treatment can be observed in adolescent patients, however, it is not associated with remission at six months.