Evaluation of Methanolic Extract of Clitoria ternatea Hepatoprotective & Nephroprotective Activity in Rats

摘要

Objective: The aim of the study was to investigate the nephroprotective & hepatoprotective activity of methanolic extract of Clitoria ternatea in Cisplatin & CClsub4/sub induced in rats Methods : Methanolic extract of aerial part of Clitoria ternatea plant was studied for its Nephroprotective & Hepatoprotective activity in animal experiment models. Nephrotoxicity was induced by Cystone 16 mg/kg b.w . Standard drug was taken Silymarin .Test drug were given methanolic extract Clitoria ternatea 500 mg/kg , 1000 mg/kg . Hepatoxicity was induced by CClsub4/sub .Standard drug was taken cisplatin 100 mg/kg . Test drugs were given extract of Clitoria ternatea 500 mg/kg & 1000 mg/kg as per b.w Results : In Hepatoprotective activity positive control group was provided with CClsub4/sub and increased SGPT , SGOT , ALP level compare to negative control group whereas Test(2) group was provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased SGPT , SGOT , ALP level compare to standard group. In nephroprotective activity positive control group was provided with CClsub4/sub increased Urea and creatinine level where as Test(2) group are provided with methanolic extract of Clitoria ternatea 1000 mg/kg decreased urea and creatinine level Conclusion: On evaluating biochemical parameters it was found that methanolic extract of Clitoria ternatea 1000 mg/kg showed hepatoprotective and nephroprotective activity in rats.