Epicardial adipose tissue affects the efficacy of left atrial posterior wall isolation for persistent atrial fibrillation

摘要

Background Epicardial adipose tissue (EAT) contributes to atrial fibrillation (AF). However, its impact on the efficacy of left atrial posterior wall isolation (LAPWI) is unclear. Methods Forty‐four nonparoxysmal AF patients underwent LAPWI after pulmonary vein isolation. EAT overlap on LAPWI was assessed by fusing computed tomography images with electro‐anatomical mapping. Results During the 21?±?7?months of follow‐up, AF recurred in 10 patients (23%). The total and left atrial EAT volumes were 113?±?36 and 33?±?12?cmsup3/sup, respectively. No differences were found between the AF‐free and AF‐recurrent groups regarding EAT volume. The EAT overlaps on LAPWI lines and LAPWI area were 1.2?±?1.0 and 0.5?±?0.9?cmsup2/sup respectively. Although no difference was found between groups regarding the EAT overlap on LAPWI area, the AF‐free group had a significantly larger EAT overlap on LAPWI lines (1.4?±?1.0 vs 0.6?±?0.6 cmsup2/sup, P =?.014). Multivariate analysis identified EAT overlap on LAPWI lines as an independent predictor of AF recurrence (hazard ratio: 0.399, 95% confidence interval: 0.178‐0.891, P =?.025). Kaplan‐Meier analysis revealed that, during follow‐up, 92% of the large EAT overlap group (≥1.0?cmsup2/sup) and 58% of the small EAT overlap group (1.0?cmsup2/sup) remained AF‐free ( P =?.008). Conclusions EAT overlap on LAPWI lines is related to a high AF freedom rate. Direct radiofrequency application to EAT overlap may be necessary to suppress AF.