The relationship between interferon-gamma (INF-γ) single nucleotide polymorphism +874(T/A) and occurrence risk of aplastic anemia: a meta-analysis

摘要

div class="hlFld-Abstract test" Objective: This meta-analysis was designed to investigate the association between interferon-gamma (IFN-γ) polymorphisms and occurrence risk of aplastic anemia. Methods: Literature search was conducted in PubMed, Embase and Cochrane Library up to April 2018. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by R 3.12. Results: Total five studies with 304 aplastic anemia patients and 588 controls were included. The statistically significant results were found in the following models: allele genetic model (T vs A: OR?=?2.1749, 95% CI?=?1.6825–2.8114, P ?0.01), additive genetic model (TA vs AA: OR?=?2.1071, 95% CI?=?1.3962–3.1799, P ?0.01; TT vs AA: OR?=?4.5788, 95% CI?=?2.6606–7.8797, P ?0.01), recessive genetic model (TT vs AA?+?TA: OR?=?2.5579, 95%?=?1.6680–3.9226, P ?0.01), dominant genetic model (TT?+?TA vs AA: OR?=?2.5599, 95%?=?1.7424–3.7611, P ?0.01), the results suggested that the increased occurrence risk of aplastic anemia is significantly associated with the IFN-γ polymorphism. Conclusions: Patients with IFN-γ genotype carrying allele T have higher occurrence risk of aplastic anemia.