Clinical Correlation between Plasma Homocysteine Level and Coronary Artery Disease in Indian Patients

摘要

>Objective: style="font-family:;" "=""> style="font-family:Verdana;"> The aim of this study was to evaluate correlation between plasma homocysteine and coronary artery disease (CAD) in Indian patients. style="font-family:Verdana;">Methods: style="font-family:Verdana;"> This study included 150 patients, 100 subjects in study group with angiographically diagnosed CAD and 50 subjects in control group with a normal coronary angiogram. In the study group, patients were divided into three subgroups style="font-family:Verdana;">viz style="font-family:Verdana;">. style="font-family:;" "=""> style="font-family:Verdana;">: CAD only, CAD with hypertension and CAD with type 2 diabetes mellitus. Plasma homocysteine, lipid profile and other risk factors were compared. style="font-family:Verdana;">Results: style="font-family:Verdana;">Mean homocysteine levels in study group (38.34 ± 15.25 μmol/L) were significantly higher (p < 0.01) than control group (9.41 ± 4.22 μmol/L). No association was found between homocysteine level and conventional risk factors. Furthermore, no significant correlation was found between plasma homocysteine and lipid components in different groups of patients. style="font-family:Verdana;">Conclusion: style="font-family:Verdana;">The study demonstrated that increased levels of homocysteine are independently related to CAD. However, further studies involving a larger sample size will be required to substantiate the findings of the current study.