Mechanisms of Endothelial Regeneration and Vascular Repair and Their Application to Regenerative Medicine

摘要

Endothelial barrier integrity is required for maintaining vascular homeostasis and fluid balance between the circulation and surrounding tissues and for preventing the development of vascular disease. Despite comprehensive understanding of the molecular mechanisms and signaling pathways that mediate endothelial injury, the regulatory mechanisms responsible for endothelial regeneration and vascular repair are incompletely understood and constitute an emerging area of research. Endogenous and exogenous reparative mechanisms serve to reverse vascular damage and restore endothelial barrier function through regeneration of a functional endothelium and re-engagement of endothelial junctions. In this review, mechanisms that contribute to endothelial regeneration and vascular repair are described. These mechanisms could be targeted to improve outcome in diseases that are characterized by vascular injury, such as atherosclerosis, restenosis, peripheral vascular disease, sepsis, and acute respiratory distress syndrome. Future studies to further improve current understanding of the mechanisms that control endothelial regeneration and vascular repair are also highlighted. Recommended articles Citing articles (0) Supported in part by NIH grants R01HL148810 (Y.Y.Z.), R01HL123957 (Y.Y.Z.), R01HL133951 (Y.Y.Z.), R01HL140409 (Y.Y.Z.), and R35HL140014 (M.L.I.A); and American Heart Association Career Development Award 19CDA34500000 (C.E.E.). Disclosures: None declared. View Abstract ? 2020 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved. Recommended articles No articles found. Citing articles Article Metrics View article metrics About ScienceDirect Remote access Shopping cart Advertise Contact and support Terms and conditions Privacy policy We use cookies to help provide and enhance our service and tailor content and ads. By continuing you agree to the use of cookies . Copyright ? 2020 Elsevier B.V. or its licensors or contributors. ScienceDirect ? is a registered trademark of Elsevier B.V. ScienceDirect ? is a registered trademark of Elsevier B.V.