Parathyroid hormone is associated with prostate cancer

摘要

BackgroundThe present study investigated the association of serum parathyroid hormone (PTH), vitamin D, and calcium levels with prostate cancer (CaP).MethodsThe study population consisted of an experimental group [459 patients including 216 patients with CaP and 243 patients with benign prostate hyperplasia (BPH)] and a prostatectomy group (47 patients who underwent radical prostatectomy). Patients with serum creatinine levels >1.4?mg/dl, parathyroid disease, and/or PTH levels <10 pg/ml were excluded. Patients with CaP and patients with BPH were compared, and the correlation between serum parameters and clinical data was determined. Preoperative and postoperative PTH levels were compared in the prostatectomy group.ResultsMean PTH levels were 41.67?±?28.82 and 27.06?±?17.32 pg/ml in the CaP and BPH groups, respectively (p?20?ng/ml), Gleason score (≤7 or ≥8), and stage (≤T3 or?≥?T4), there was no significant difference in PTH levels between the two groups. Mean postoperative PTH levels (26.93?±?13.58 pg/ml) were significantly lower than preoperative PTH levels (36.71?±?21.04 pg/ml) in the same patients who underwent radical prostatectomy.ConclusionSerum PTH levels were higher in patients with CaP than in patients with BPH?and decreased significantly after radical prostatectomy. The present results suggest an association between serum PTH and CaP. Further large cohort studies are necessary to validate the present data.