Representation of foreseeable choice outcomes in orbitofrontal cortex triplet-wise interactions

摘要

Neuronal responses can differ substantially during repetitions of the same tasks; however, they are often coordinated (shared) across multiple neighboring neurons. Such correlation between neurons has been related to the capacity of the brain to take decisions, but specifically how this relation is established is still under study. In this work, we address this question by focusing on an intriguing case study, the orbitofrontal cortex, since this brain area has been found in various studies to be useful for decision-making. Here, we question whether orchestrated groups of neurons encode sufficient information for optimizing their decision strategy; that is, whether the outcome of a choice can be predicted or not on the basis of previous experience. We thus designed a decision-making task for a rat in which some of the correct choices can be predicted. We found that only successful outcomes that can actually be predicted were robustly encoded over time. This finding was shown by analyzing sufficiently complex interactions between three neurons, whilst more complex orchestrations did not add further insights. Thus, we propose that coordinated responses of up to three neurons in the OFC could contribute to the capacity of the animal to take the optimal decision.