Engineering mesenchymal stromal/stem cell-derived extracellular vesicles with improved targeting and therapeutic efficiency for the treatment of central nervous system disorders

摘要

Treatment forcentral nervous system(CNS) disorders is known to belimited by thelowregenerative potential of neurons,and thus neurodegenerativeinsults became known as nearly irreversibleailments. Functionalrecovery foracquired CNS disorders, such as spinalcord injury (SCI), traumatic brain injury, ischemicstroke, Alzheimer’s disease, Parkinson’s disease, multiplesclerosis (MS),and forcongenitalCNS abnormalities, such as spina bifida, is notspontaneousand effectivetreatmentsarelimited to non-existent.