This paper is focused on the possibility of using the costs simulation in supply chain, which are on relative high level. In the first part we focus on the theoretical basis of supply chains in E-business and the possibilities of using Monte Carlo simulation. In the second part we focus on the costs simulation in the supply chain in the company of machine industry. In the past, this company used traditional forms of communication and management within the supply chain. With the development of the company and modern technologies it plans to use various forms of E-business. Before it, we have to analyze the costs that will be spent on supply chain management, if we use E-business solutions. Our goal is to determine the costs using Monte Carlo simulation, which must necessarily be spent on business activities in the supply chain management using E-business.
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