The Purine Requirement of Staphylococcus flavocyaneus

摘要

SUMMARY: Staphylococcus flavocyaneus, grown in chemically defined media, requires a purine; adenine, hypoxanthine, their respective ribosides and ribotides, 4-amino-5-imidazolecarboxamide or 4-amino-5-imidazolecarboxamidine were effective. Per mole, the ribotides (2′, 3′ or 5′) were most efficient. Growth with effective purines is inhibited by guanine and certain unnatural purines. Inhibition of growth by purines may involve two mechanisms: one concerned with the synthesis of unnatural nucleic acid; the other with a crippling of ribose metabolism.