Intravoxel incoherent motion diffusion-weighted imaging evaluated the response to concurrent chemoradiotherapy in patients with cervical cancer

摘要

To evaluate the application of multiple b values diffusion-weighted imaging based on biexponential signal decay model to predict the response to concurrent chemoradiotherapy in cervical cancer patients. This prospective study enrolled 28 patients (mean age: 50.89 ± 10.70 years) with cervical cancer confirmed by biopsy who received concurrent chemoradiotherapy . Pelvic magnetic resonance scans were performed 2 weeks before, 7 days and 21 days after the initiation of therapy, and 1 month after the end of the treatment. Diffusion-weighted imaging with b values of 0, 50, 450, and 850 s/mm 2 were performed, and tumor volume, means of tumor apparent diffusion coefficient (ADC) min , ADC mean , ADC slow , ADC fast , and F fast were measured. Pretreatment ADC min and ADC slow of good outcome group were significantly higher than those of poor outcome group ( P .05). At the 7th day of the treatment, F fast and its change rate of good outcome group were significantly higher than those of poor outcome group ( P .05). At the 7th day and 21st day of the treatment, F fast showed a slowly increasing tendency with no significant difference compared with pretreatment value in poor outcome group ( P .05). One month post-treatment, only ADC slow change rate was significantly higher in good outcome group than that in poor outcome group. Intravoxel incoherent motion -related ADC values could be utilized to better predict the outcome of cervical cancer chemoradiotherapy .