Editorial: New Insights into Estrogen/Estrogen Receptor Effects in the Cardiac and Skeletal Muscle

摘要

Decreased levels of the steroid hormone estrogen at menopause are associated with an increasedincidence of cardiovascular disease and loss of skeletal muscle mass and strength. Consequently, ithasbeengenerallyexpectedthatestrogenmaybeacrucialprotectivefactoragainstthedevelopmentof cardiovascular disease and that it may be implicated in the regulation of skeletal muscle functionin women. Estrogen signals through the classical nuclear estrogen receptors (ER) α and β, as wellas the membrane G protein-coupled receptor GPR30 (also referred to as GPER), via the genomicor non-genomic pathway.