Molecular and epigenetic mechanisms associated with extinction of fear memory: a systematic review

摘要

Introduction: The present systematic review aims to analyze articles between 2011 and 2017 thatdescribe the involvement of epigenetic and molecular mechanisms associated with extinction of fearmemory. Methods: Inclusion and exclusion criteria were considered to filter the final articles extractedfrom Science Direct, Pubmed and Google Scholar. Results: From a total of 461 articles, 13 attended thecriteria and were displayed in a table divided into: Objective, Brain region, techniques and reference.These final articles were critically analyzed and compared between each other. Discussion: Analysis ofdrug efficiency and molecular mechanisms involved in extinction and/or consolidation of fear memoryin mice and rats may elucidate and thus contribute in the treatment of obsessive-compulsive disorder,anxiety, phobia, panic and posttraumatic stress disorder.