Synthesis, characterization, and anticancer activity against human breast cancer cell-line T47D studies of metal ion Cu(II) complex with 2,4,5-triphenylimidazole ligand

摘要

The complex of metal ion Cu(II) with the ligand 2,4,5-trifenilimidazol has been successfully synthesized with mole ratio of metal and ligand 1:2 in N,N-dimethylformamide as a solvent. Complex synthesis results obtained green light crystalline solid. Complex absorbs UV-Vis light at 529 nm. Fourier transform infrared (FTIR) characterization results indicate occurrence of bonding of metals and ligand that is Cu-N in region 422.38 cm-1. Results of elemental analyzer and Atomic Absorption Spectroscopy (AAS) analysis show the complex formed has the formula [Cu(L)2(H2O)2].Cl2. The molecular formula is also supported by the Thermal Gravimetric Analyzer data. Thermal Gravimetric Analyzer (TGA) analysis results showed that there was no water in the crystalline complex compounds. The cytotoxicity test complex compounds made by the method of 3-(4,5-dimetiltiazol-2-yl)-2,5-difeniltetrazolium bromide (MTT) and the IC50 value of complex obtained 72.139 μg/ml.