Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin

Fabian A. Grimm; Hans-Joachim Lehmler; Xianran He; Larry W. Robertson; Michael W. Duffel

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Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin

机译：多氯化双烯基的硫酸化代谢物是甲状腺激素运输蛋白Transthyretin的高亲和力配体

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Background: The displacement of l-thyroxine (T4) from binding sites on transthyretin (TTR) is considered a significant contributing mechanism in polychlorinated biphenyl (PCB)-induced thyroid disruption. Previous research has discovered hydroxylated PCB m

机译：背景：L-甲状腺素（T4）从Transthyretin（TTR）的结合位点的位移被认为是聚氯联苯苯基（PCB）的显着贡献机制 - 诱导的甲状腺破坏。以前的研究发现了羟基化的PCB m

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《Environmental health perspectives.》 |2013年第6期|共6页
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Fabian A. Grimm; Hans-Joachim Lehmler; Xianran He; Larry W. Robertson; Michael W. Duffel;
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1. Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin [J] . Grimm Fabian A., Lehmler Hans-Joachim, He Xianran, Environmental health perspectives. . 2013,第4a6期

机译：多氯联苯的硫酸盐代谢产物是甲状腺激素转运蛋白运甲状腺素蛋白的高亲和力配体。
2. Binding and activity of sulfated metabolites of lower-chlorinated polychlorinated biphenyls towards thyroid hormone receptor alpha [J] . Ren Xiao-Min, Li Chuan-Hai, Zhang Jian-Qing, Ecotoxicology and Environmental Safety . 2019,第SEPa期

机译：低氯多氯联苯的硫酸盐代谢产物与甲状腺激素受体α的结合和活性
3. Blood levels of polychlorinated biphenyls and their hydroxylated metabolites in Baikal seals (Pusa sibirica): Emphasis on interspecies comparison, gender difference and association with blood thyroid hormone levels [J] . Daisuke Imaeda, Kei Nomiyama, Tatsuya Kunisue, Chemosphere . 2014,第nova期

机译：贝加尔湖海豹（Pusa sibirica）中的多氯联苯及其羟基化代谢物的血药浓度：强调种间比较，性别差异以及与血甲状腺激素水平的关系
4. Polychlorinated Biphenyls, Thyroid Hormones, and Neuropsychological Functioning over a 14-Year Period, among Healthy, Older Adults from New York State [C] . Eva M Tanner, Michael S. Bloom, Wei Wang, Joint annual meeting of the International Society of Exposure Science and the International Society for Environmental Epidemiology . 2018

机译：纽约州健康老年人中的多氯联苯，甲状腺激素和神经心理学功能在14年内
5. Toxicological and therapeutic implications of interactions between polychlorinated biphenyl sulfates and human transthyretin [D] . Grimm, Fabian Alexander 2014

机译：多氯联苯硫酸盐与人运甲状腺素蛋白相互作用的毒理学和治疗意义
6. Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin [O] . Fabian A. Grimm, Hans-Joachim Lehmler, Xianran He, 2013

机译：多氯联苯的硫酸盐代谢产物是甲状腺激素转运蛋白运甲状腺素蛋白的高亲和力配体。
7. Developmental Exposure to Polychlorinated Biphenyls Exerts Thyroid Hormone-Like Effects on the Expression of RC3/Neurogranin and Myelin Basic Protein Messenger Ribonucleic Acids in the Developing Rat Brain1 [O] . R. Thomas Zoeller, Amy L. S. Dowling, Anna A. Vas 2000

机译：多氯联苯的发育暴露对培养大鼠脑中的RC3 /神经蛋白和髓鞘碱性信使核糖核酸的表达施加甲状腺激素样效果
8. Pesticide Monitoring Study. Evaluation of Silicic Acid Column Pesticide/Polychlorinated Biphenyl Separation Procedure:Recovery and Elution Patterns of 24Pesticides and Pesticide Metabolites and Two Polychlorinated Biphenyls. [R] . suprock,john f. vinopal, j. howard 1979

机译：农药监测研究。评价硅酸柱农药/多氯联苯分离程序：24种农药和农药代谢物和两种多氯联苯的回收和洗脱模式。

Sulfated Metabolites of Polychlorinated Biphenyls Are High-Affinity Ligands for the Thyroid Hormone Transport Protein Transthyretin

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