Thyroid Hormone Understanding Branches Out: Insights into PBDE Impacts on Brain Development

摘要

Polybrominated diphenyl ether (PBDE) flame retardants and their hydroxylated metabolites are structurally similar to thyroid hormone. A detailed study now provides one of the most insightful assessments to date of how environmentally relevant levels of PBDEs may impair brain development by interfering with thyroid hormone receptor (TR)–mediated transcription [EHP 119(2):168–175; Ibhazehiebo et al.].