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The proportion of peripheral blood Tregs among the CD4+ T cells of autoimmune thyroid disease patients: a meta-analysis

机译:自身免疫性甲状腺疾病患者的CD4 + T细胞外周血血瘀的比例:META分析

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Autoimmune thyroid disease (AITD) is characterized by a loss of self-tolerance to thyroid antigen. Tregs, whose proportions are controversial among CD4+ T cell from AITD patients (AITDs), are crucial in immune tolerance. Considering that drugs might affect Treg levels, we assumed that the differences originated from different treatment statuses. Thus, we performed a meta-analysis to explore proportions of Tregs in untreated and treated AITDs. PubMed, Embase and ISI Web of Knowledge were searched for relevant studies. Review Manager 5.3 and Stata 14.0 were used to conduct the meta-analysis. Subgroup analysis based on different diseases and cell surface markers was performed. Egger linear regression analysis was used to assess publication bias. Approximately 1,100 AITDs and healthy controls (HCs) from fourteen studies were included. Proportions of Tregs among CD4+ T cells of untreated AITDs were significantly lower than those in HCs (p = 0.002), but were not in treated patients (p = 0.40). Subgroup analysis revealed lower proportions of Tregs in untreated Graves’ disease patients (GDs) (p = 0.001) but did not show obvious differences in untreated Hashimoto’s thyroiditis patients (HTs) (p = 0.62). Furthermore, proportions of circulating FoxP3+ Tregs were reduced in untreated GDs (p 0.00001) and HTs (p = 0.04). No publication bias was found. In this first meta-analysis exploring proportions of circulating Tregs among CD4+ T cells of AITDs with different treatment statuses, we found that Tregs potentially contribute to the pathogenesis of AITD but function differently in GD and HT. Remarkably, FoxP3+ Tregs, which were decreased in both diseases, might be promising targets for novel therapies.
机译:自身免疫性甲状腺疾病(AITD)的特征在于对甲状腺抗原的自耐受性的丧失。 Tregs,其比例来自来自AITD患者(AITDS)的CD4 + T细胞中的争议性,对免疫耐受性至关重要。考虑到药物可能影响特雷格水平,我们认为源自不同的治疗状况。因此,我们进行了荟萃分析,以探讨未经处理和处理的AITDS中的Tregs的比例。搜索了有关研究的PUBMED,EMBASE和ISI网络。审查Manager 5.3和Stata 14.0用于进行Meta分析。进行基于不同疾病和细胞表面标记的亚组分析。 Egger线性回归分析用于评估出版物偏见。包括来自十四项研究的大约1,100个AITDS和健康对照(HCS)。未处理的AITDS的CD4 + T细胞中的Tregs的比例显着低于HCs(p = 0.002),但未在治疗患者中(p = 0.40)。亚组分析显示未经处理的坟墓疾病患者(GDS)中的Tregs比例较低(P = 0.001),但未显示出未经处理的哈希莫氏菌炎患者(HTS)的明显差异(P = 0.62)。此外,在未处理的GDS(P <0.00001)和HTS中,将循环FoxP3 + Tregs的比例降低(P = 0.04)。没有发现出版物偏见。在该第一荟萃分析中,探讨具有不同治疗状态的AITDS的CD4 + T细胞中循环Tregs的比例,我们发现Tregs可能导致AITD的发病机制,但在GD和HT中的功能不同。值得注意的是,在两种疾病中减少的Foxp3 + Tregs可能是对新疗法的有前途的目标。

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