Glucose-6-phosphate dehydrogenase deficiency in neonatal hyperbilirubinemia and its relationship with severity of hyperbilirubinemia

摘要

Objective: To determine the frequency of Glucose-6-Phosphate dehydrogenase deficiency in neonates with hyperbilirubinemia andto find the association between level of G6PD deficiency and severity of hyperbilirubinemia.Study Design: Cross sectional Descriptive studyPlace and Duration: Hematology and Pediatrics Departments of Shaikh Zayed Hospital, Lahore from November 1st, 2012 to January1st, 2014.Methodology: We included 100 neonates with hyperbilirubinemia after excluding the other risk factors. Initially screening for G6PDdeficiency done with qualitative methods and deficient neonates were confirmed with quantitative method. History, examinationand investigations like routine hematological investigations and total and direct bilirubin, Coomb’s test, G6PD qualitative andquantitative assay were done in all subjects.Results: Out of 100 neonates 6% were G6PD deficient and in majority jaundice appeared on third day. For G6PD deficient neonatesmaternal age was found to be higher (29.83±1.17 years) as compared to that for normal G6PD neonates. Bilirubin was higher with amean value of 24.48±7.0 mg/dl and platelets were lower in deficient group with a mean value of 166.33±58.64 x 109/L.Conclusion: In newborns presenting with neonatal jaundice, screening for G6PD deficiency should be considered. There isassociation between lower enzyme activity and hyperbilirubinemia, and an early recognition followed by treatment to avoidcomplications is advisable.