tert-Butyl 4-{3-[6-(4-meth-oxy-phen-yl)-2-methyl-pyrimidin-4-yl]quinolin-2-yl}piperazine-1-carboxyl-ate

摘要

The asymmetric unit of the title compound, C 30 H 33 N 5 O 3 , contains two independent mol-ecules, A and B . In mol-ecule A , the tert -butyl 4-methyl-piperazine-1-carboxyl-ate group was refined as disordered over two sets of sites with an occupancy ratio of 0.821?(4):0.179?(4). The piperazine ring adopts a chair conformation in both mol-ecules. The dihedral angles between the pyrimidine ring and meth-oxy-phenyl ring are 20.27?(14) and 8.72?(11)° for mol-ecules A and B , respectively. The quinoline ring system makes dihedral angles of 30.68?(11) and 37.76?(10)° with the pyrimidine ring in mol-ecules A and B , respectively. In the crystal, C—H?O hydrogen bonds link the mol-ecules into chains along [100].