Anti-inflammatory, Anti-oxidant and Anti-microbial Properties of Polyherbal Formulation in Acne Treatment

摘要

Nowadays, individual herbs are insufficient to achieve a desired therapeutic effect. When it is optimized as multiple herbs composition in a particular ratio it will give a therapeutic effect in a better way with reduced toxicity. In order to develop such an intervention, the present study was intended to develop a polyherbal cream from extracts of Santalum album, Rubia cordifolia, Ocimum sanctum, Emblica officinalis, Glycyrrhiza glabra, Persea americana, Simmondsia chinensis, Vitis vinifera. The present study emphasizes on screening of polyherbalism as anti-inflammatory, antioxidant and anti-microbial in Acne treatment. The polyherbal cream showed significant activity against P. acnes and S. auerus with diameter of 10 mm and 15 mm inhibition zone respectively. The polyherbal cream exhibited moderate antioxidant activity with IC50 value of 8.9 mg/ml. Topical anti-inflammatory activity was assessed by carrageenan induced paw oedema compared with Diclofenac. The percentages of edema inhibition were 79.9 % (p < 0.01) after five hours. The outcome of the study suggested that polyherbal cream could be possible to use as the natural anti-acne formulations.