Sacubitril/valsartan improves right ventricular function in a real-life population of patients with chronic heart failure: The Daunia Heart Failure Registry

摘要

BackgroundPrevious studies and case-series showed improvement in left ventricular (LV) function and reverse remodeling after sacubitril/valsartan therapy in real-world studies. We therefore aimed to evaluate whether also right ventricular (RV) function may improve after sacubitril/valsartan therapy.MethodsSixty consecutive patients with chronic heart failure and NYHA class II-III were followed up for 12?months after therapy with sacubitril/valsartan. Left and (RV) function was assessed at baseline and after 12?months of therapy.ResultsAt 12-month control, therapy with sacubitril/valsartan was associated with a significant improvement in a series of echo parameters: LVEF (p?