Impact of disease activity on health related quality of life in patients with Beh?et's disease: A cross-sectional study

摘要

BackgroundBeh?et's syndrome (BD) is a systemic inflammatory vasculitis of unknown aetiology, affecting vessels of different types, sizes and locations and characterized by recurrent episodes of acute inflammation, including mucocutaneous manifestations (oral aphthous ulcers, genital ulcers and skin lesions) and gastrointestinal, musculoskeletal, neurological, ophthalmic and vascular involvement which lead to a significant morbidity and impaired health related quality of life (HRQoL). Few studies reported impact of disease activity on HRQoL.ObjectiveTo assess the impact of BD activity on HRQoL.Patients and methodsThis cross sectional study included patients with Beh?et's disease diagnosed according to the International Study Group criteria 1990 for BD. Age of the patients, sex, smoking status, educational level, disease duration, organ involvement, age at disease onset, and medications used were recorded. Beh?et's Disease Disease activity was assessed using Beh?et's Disease Current Activity Form (BDCAF) and HRQoL was evaluated using The Short Form-36 (SF-36).ResultsA total of 71 patients (45 males, 26 females) with Beh?et's disease were enrolled in this study. Mean age of patients was 36.0?±?10.8 years, Males represented the majority of patients (63.4%). BDCAF was significantly and negatively correlated with total SF-36 score (standardized β?=?? 0.520, p?