In Vitro Antioxidant and Hypoglycemic Potentials of Musa paradisiaca Aqueous Extract on Alloxan Induced Diabetic Albino Rats

摘要

Diabetes is one of the common pathologies involving oxidative stress in its aetiology and complications. This research was carried out to evaluate the antioxidant and hypoglycaemic properties of aqueous extract of unripe Musa paradisiaca on blood glucose of alloxan-induced albino rats. Thirty (30) albino rats were divided into six groups, each group containing five rats. Group 1 (positive control) Groups 2 (negative control) and Group 3, 4, and 5 received 140, 180 and 220 mg / kg per body weight of Musa paradisiaca once daily for 14 days. Group 6 were administered chlorpropamide 84 mg / kg per body weight. The serum concentration of glucose of all the rats in each group was determined 72 hours after induction of diabetes and on the 7 th and 14 th days. There was significant (p0.05) reduction of serum glucose in Groups 3, 4 and 5 when compared to the negative control group on day 7 th and 14th. Group 6 showed no significant (p0.05) reduction of serum glucose compared to 5. The extract also increased the total reduced glutathione (GSH) level, Superoxide dismutase (SOD) and Catalase activities in vitro . The aqueous extract of Musa paradisiaca possesses antioxidant and anti-diabetic effects on alloxan induced diabetic rats.