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Lenalidomide (LENA) Hybrid Gold Complex Nanoparticles: Synthesis, Physicochemical Evaluation, and Perspectives in Nanomedicine

机译:Lenalidomide(Lena)杂交金复合纳米粒子:纳米医生的合成,物理化学评估和观点

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摘要

This paper proposes a fast methodology to synthesize hybrid lenalidomide gold nanoparticles. Gold (HAuCl_(4)) is chelated with an antiangiogenic compound (lenalidomide (LENA)) and diacid poly(ethylene glycol) (PEG) as capping agent and reagent. The suggested synthesis is rapid and results in gold nanoparticles (AuNPs) with enhanced drug solubility. The binding between LENA, PEG, and Au(III) ions forms hybrid nanovectors named LENA IN PEG-AuNPs, which were characterized by different spectroscopic techniques (Raman and UV–vis), transmission electron microscopy (TEM), and compared with LENA ON PEG-AuNPs, in which the drug was grafted onto gold surface by carbodiimide chemistry (1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N -hydroxysuccinimide, EDC/NHS). The effective drug delivery under pH conditions was also reached, combined with doxorubicin (DOX) to improve the synergic chemotherapy and stability under experimental conditions. For biomedical purposes, hybrid gold nanocarriers were conjugated with folic acid (FA), which is specifically overexpressed in cancer cells. This paper will be very important in the domain of therapeutic gold complex, paving the way for reaching progress of novel drug carrier synthesis in nanomedicine.
机译:本文提出了一种快速的方法来合成杂交氰化物金纳米颗粒。金(Haucl_(4))用抗血管生成化合物(Lenalaldoromide(Lena))和二酸聚(乙二醇)(PEG)作为封端剂和试剂螯合。建议的合成迅速,导致金纳米颗粒(AUNP),具有增强的药物溶解度。 Lena,PEG和Au(III)离子之间的结合在PEG-AUNP中形成名为Lena的杂交纳米型,其特征在于不同的光谱技术(拉曼和UV-VI),透射电子显微镜(TEM),并与Lena相比PEG-AUNPS,其中通过碳二亚胺化学(1-乙基-3-(3-二甲基氨基丙基)碳二亚胺/ N-羟基琥珀酰亚胺,EDC / NHS)将药物接枝到金表面上。还达到了pH条件下的有效药物递送,与多柔比星(DOX)联合在实验条件下改善协同化疗和稳定性。对于生物医学目的,杂交金纳米载体与叶酸(FA)缀合,其在癌细胞中特别过表达。本文将在治疗黄金复合体领域非常重要,铺平了纳米杂草新药载体合成的进展。

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