金核壳纳米粒子的控制合成及其生物复合

摘要

合成了一系列Au/SiO2核壳纳米粒子,并详细研究了Au纳米壳层的生长过程.发现在金纳米壳层形成的过程中存在着2个竞争反应.利用这一发现,可将金纳米壳层的吸收峰从524 nm连续调谐至980 nm处.恩度是一种临床抗癌药物,我们首次将其生物复合于吸收峰位于808 nm的Au/SiO2壳层表面,得到Au/SiO2-Endo,通过FTIR测试证明该生物复合成功.将恩度特殊的饿杀肿瘤特性以及对肿瘤具有特异识别能力,与Au/SiO2纳米壳层结构的光学可调谐特性以及良好的光热转换能力复合于一体,我们期望得到一种治疗肿瘤效果更强的新型药物.%A series of Au/SiO2 nanoshells was synthesized and the process of their growth was studied in detail.Two competing reaction ways during the process of the Au nanoshell's growth were found.Utilizing this rule,the plasmon absorption of these nanoshells was continuously tuned from 524 nm to 980 nm.Endostar,a commercial anti-tumor medicine was firstly tried to bioconjugate to the surface of Au/SiO2 nanoshells whose absorption peak was at 808 nm.We obtained the new composition Au/SiO2-Endo,and the FTIR spectra proved this successful bioconjugation.By combining the specific function of the starving tumor and a certain target tropism to tumor of Endostar with the easy tunability and favorable photothermal effect of gold nanoshells,it is expected that a novel kind of composite medicine with stronger ablation for tumor can be obtained by the present method.