Anti-inflammatory and Anti-ulcer Activities of New Fused Thiazole Derivatives Derived from 2-(2-Oxo-2H-chromen-3-yl)thiazol-4(5H)-one

摘要

The reaction of the 2-(4-oxo-4,5-dihydrothiazol-2-yl)acetonitrile ( 1 ) with salicylaldehyde ( 2 ) in 1,4-dioxane containing a catalytic amount of piperidine gave the coumarin derivative 3 . The latter reacted with different reagents to give pyrano[4,5- b ]thiazole, pyrido[4,5- b ]thiazole and thieno[5,4- b ]thiazole dereivatives. The anti-inflammatory and anti-ulcer activities of the newly synthesized products were evaluated and the results showed that compounds 7a , 8a , 10b , 13b , 15b , 18a , 19b , 19c , and 19d showed higher activity compared to the rest of the compounds. In addition to this, toxicity of such active compounds was studied against shrimp larvae where compounds 10b , 18a , 19c and 19d showed to be non-toxic against the tested organisms.