新型2-(2-氨基噻唑-4-基)-2-(Z)-甲氧亚胺基乙酸酯类衍生物的合成及其抑菌活性

摘要

以乙酰乙酸甲(乙)酯,醛和酰氯为主要原料,合成了8个2-(2-氨基噻唑-4-基)-2-(Z)-甲氧亚胺基乙酸酯类衍生物(其中6个未见文献报道),其结构经1H NMR,IR和MS表征.初步抑菌活性测试结果表明,在给药量为200 mg·L-1时,化合物对小麦赤霉病菌和马铃薯干腐病菌有较好的抑菌活性.%Eight (Z) -2-(2-aminothiazol-4-yl) -2-(methoxyimino) acetate derivatives ( six of them were new derivatives) were synthesized from methyl (ethyl) acetoacetates, aldehydes and acyl chlorides. The structures were characterized by 1H NMB, IR and MS. The preliminary bioassays tests resuits showed that all derivatives exhibited certain antibacterial activities against Fusariurn graminearum and Fusarium solani in 200 mg · L-1.