COMPARATIVE STUDY REGARDING THE INFLUENCE OF PERFTORAN-HSS ASSOCIATION ON BLOOD GASES PARAMETERS IN RAT MODEL OF HAEMORAGIC SHOCK

摘要

This study tested Perftoran blood substitute and a association of Perftoran and Hypertonic Saline Solution for the use in haemorrhagic shock in rats. Four groups were made (n=10): P (Perftoran), PSH (Perftoran HSS), SH (HSS) and M (Control). Haemorrhagic shock was induced by controlled exsanguination until MAP decreased below 45 mmHg. Resuscitation therapy was initiated after 30 of shock and was made with 0.9% NaCl solution in group M, 3.5% NaCl solution in group SH, Perftoran in group P and Perftoran associated with 2.9% NaCl solution in group PSH. Data analysis shows that both Perforan and PSH are efficient in oxygen delivering and volume resuscitation.