Maternal plasma lipid levels across pregnancy and the risks of small-for-gestational age and low birth weight: a cohort study from rural Gambia

摘要

Sub-optimal maternal lipid levels during pregnancy may be implicated in the pathophysiological mechanisms leading to low birth weight (LBW) and small-for-gestational-age (SGA). We aimed to determine whether maternal lipid levels across pregnancy were associated with birth weight and the risks of LBW and SGA in rural Gambia. This secondary analysis of the ENID trial involved 573 pregnant women with term deliveries. Plasma levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and triglycerides (TG) were analyzed at enrolment (mean (SD)?=?13.9 (3.3) weeks gestation), 20 and 30?weeks gestation as continuous variables and percentile groups. Regression models with adjustment for confounders were used to examine associations between gestational lipid levels and birth weight and the risks of LBW (birth weight 90th percentile) LDL-c at 30?weeks gestation was associated with a 55% lower risk of SGA compared with referent LDL-c (P?=?0.017). Increased levels of TC (β?=?1.3, P?=?0.027) at 20?weeks gestation and of TC (β?=?1.2, P?=?0.006) and LDL-c (β?=?1.5, P?=?0.002) at 30?weeks gestation were all associated with higher birth weight. In rural Gambia, lipid levels during pregnancy were associated with infant birth weight and the risks of LBW and SGA. Associations varied by lipid class and changed across pregnancy, indicating an adaptive process by which maternal lipids may influence fetal growth and birth outcomes. This trial was registered as ISRCTN49285450 on: 12/11/2009.