Higher serum uric acid level is inversely associated with renal function assessed by cystatin C in a Japanese general population without chronic kidney disease: the KOBE study

摘要

BackgroundSeveral epidemiological studies have reported that hyperuricemia is associated closely with renal dysfunction [1,2,3,4,5,6,7,8]. A 7-year follow-up study of Japanese subjects showed that serum uric acid (SUA) levels and increased levels of serum creatinine were significantly related, and that hyperuricemia (≥6.0?mg/dL) was associated with progression of end stage renal disease in women. In addition, maintenance of a normal SUA level was important for maintaining normal renal function [1]. Another follow-up study of Japanese individuals without chronic kidney disease (CKD) reported that the rate of CKD onset in the group with high SUA levels at baseline was greater than that in the group with a lower SUA level, and that the rate of decline in renal function per year was rapid [2]. However, there is insufficient evidence to determine whether or not gender-based SUA levels are associated with a mild decline in renal function before the onset of CKD. The level of estimated glomerular filtration rate (eGFR) assessed by cystatin C is not influenced by either muscle mass, nutrition, or physical activity status and is therefore considered to be a suitable method for evaluating mild renal dysfunction [9].This cross-sectional study examined the association between SUA level and renal function stratified according to gender in the non-CKD general population who had not been treated for cardiovascular diseases or cancer.