Analysis of association between common variants of uncoupling proteins genes and diabetic retinopathy in a Chinese population

摘要

The aim of this study was to explore the association between diabetic retinopathy (DR) and the variants of uncoupling proteins (UCPs) genes in a Chinese population of type 2 diabetes, in total and in patients of different glycemic status separately. This case-control study included a total of 3107 participants from two datasets, among which 662 were DR patients (21.31%). Eighteen tag single nucleotide polymorphisms (SNPs) of UCP1, UCP2, and UCP3 were selected as genetic markers. TaqMan probes, Sequenom MassARRAY MALDI-TOF mass spectrometry platform and Affymetrix Genome-Wide Human SNP Array were used for genotyping. Online SHEsis software was used for association analysis. Bonferroni correction was used for multiple comparisons correction. Three SNPs of UCP1: rs7688743 (A allele, OR?=?1.192, p?=?0.013), rs3811787 (T allele, OR?=?0.863, p?=?0.023), and rs10011540 (G allele, OR?=?1.368, p?=?0.004) showed association with DR after the adjustment of glucose, but only rs10011540 was marginally significantly associated with DR when Bonferroni correction was strictly applied (padj?=?0.048). In patients with uncontrolled glucose, rs7688743 (A allele, p?=?0.012, OR?=?1.309), rs10011540 (G allele, p?=?0.033, OR?=?1.432), and rs3811787 (T allele, p?=?0.022, OR?=?0.811) were associated with DR, while in participants with well controlled glucose, the rs2734827 of UCP3 was associated with DR (A allele, p?=?0.017, OR?=?0.532). Rs3811787 of UCP1 showed a protective effect to sight threatening DR (T allele, p?=?0.007, OR?=?0.490), and the association existed after the adjustment for environmental factors and the correction. In patients with uncontrolled glucose, the rs3811787 of UCP1 (T allele, p?=?0.017, OR?=?0.467) and the rs591758 of UCP3 (C allele, p?=?0.026, OR?=?0.103) were associated with STDR. While in those with well controlled glucose, only the rs7688743 of UCP1 showed a protective effect (A allele, p?=?0.024, OR?=?0.049). None of the associations remain significant when Bonferroni correction was strictly applied (all p??0.05). The rs10011540 and rs3811787 of the UCP1 gene was marginally significantly associated with DR in Chinese type 2 diabetes patients. There might be different mechanisms of DR development in patients with different glycemic status.