Hepatitis B and Hepatitis C Virus Infection among End Stage Renal Disease Patients on Maintenance Hemodialysis, Their Family Members and Dialysis Staffs - A Prevalence Study

摘要

Background: Hepatitis B (HBV) and hepatitis C virus (HCV) infection is common among patients onmaintenance hemodialysis (MHD). This study was undertaken to observe prevalence of hepatitis B and Cinfection in hemodialysis patients, their family members and dialysis staffs.Methods: In this cross-sectional study 3 groups were included as gr-1 patients on MHD, the first-degreerelatives in gr-2 and the dialysis staffs as gr-3. Clinical and laboratory investigations were done. Viral serologyincluded hepatitis B surface antigen (HBsAg) and antibody against hepatitis C virus (anti-HCV) done byenzyme linked immunosorbent sorbent assay (ELISA) method.Results: Total 150 subjects were analyzed where 50 were in gr-1, 60 gr-2 and 40 in gr-3. In gr-1 MHDpatients, HBV infection was positive in 12% and HCV in 71%. None of the viral markers were positive infamily members and dialysis staffs. Blood transfusion (BT) was taken by 76% MHD patents. The frequency ofHBV and HCV infection was of similar pattern in both BT dependent and non BT group (P=NS).When HCVpositive and negative patents were (71 vs. 29%, p<0.001) compared, dialysis duration (37 ± 34 vs. 11± 6months, p<0.001) was found higher in positive patients.Conclusion: This survey on dialysis patients showed that prevalence of hepatitis B and C virus infections washigher in Bangladeshi patients on MHD groups. Horizontal spread of these viruses is negligible in caregiversand dialysis staffs.