QTc Changes in Non-pregnant Females with Severe iron Deficiency

摘要

Background: A prolonged QT interval is a biomarker for ventricular tachyarrhythmias and a risk factor for sudden death. It is associated with a faulty storage of excess iron in the myocardium, which is described in several hereditary and acquired conditions. However, we do not have enough evidence on the fact that iron deficiency can affect the QT interval. We hypothesized that iron plays an important role in the generation and the propagation of electrical impulses at the level of the myocardial membrane and that it alters the QT interval; so we recorded the QT interval in severely anaemic, non-pregnant females and compared it with that in age and sex matched controls. Methods: 30 non-pregnant females with severe iron deficiency anaemia, Haemoglobin- 0.001). There was a significant positive correlation between the serum ferritin levels and the QTc interval. Conclusion: A shortened QTc was observed in the SIDA group because of the sympathetic over activity which was secondary to the hyper dynamic circulation.