Correlation of Serum Nitric Oxide with Haematological and Biochemical Parameters in Acute Ischaemic Stroke Patients

摘要

Nitric oxide (NO), different haematological and biochemical parameters, play an important role in the pathogenesis of Acute Ischaemic Stroke (AIS) (<24 hour).Aim: To establish a correlation between NO with haematological and biochemical parameters in AIS patients.Materials and Methods: A hospital based, cross-sectional study was done in 50 patients of AIS and 25 healthy controls. Serum NO level was measured by ELISA. Complete lipid profile, Random Blood Sugar (RBS), serum Blood Urea Nitrogen (BUN), creatinine and haemogram were assessed by automated devices. Pearson?s correlation coefficients were analysed to look for the relationship between NO with biochemical and haematological parameters. The p-value was considered significant if p<0.05.Results: Statistically highly significant (p<0.001) elevation in mean serum NO levels were observed in cases (32.06 μmol/L) as compared to controls (24.41 μmol/L). NO was positively correlated with elevated levels of Triacylglycerol (TAG), T-Chol, Low Density Lipoprotein (LDL-C), VLDL-C, RBS, and negatively correlated with High Density Lipoprotein (HDL-C), BUN, serum creatinine, Total Leukocyte Count (TLC), ESR, but none of the correlation coefficient was found to be statistically significant.Conclusion: Elevated NO and derangement of biochemical and haematological parameters may be linked to pathogenesis of AIS.