Hemodynamic Responses to EtomidateVersus Ketamine-Thiopental SodiumCombination for Anesthetic Induction inCoronary Artery Bypass Graft SurgeryPatients with Low Ejection Fraction: ADouble-Blind, Randomized, Clinical Trial

摘要

Background: During induction of anesthesia and intubation, hemodynamic changes are very important; especially in patients with coronary artery disease (CAD) and left ventricular dysfunction. A little information is available on the hemodynamic effects of a combination of ketamine-thiopental for induction of anesthesia in patients undergoing coronary artery bypass graft (CABG) surgery, with impaired ventricular function.Aim: The aim of this study was to compare the hemodynamic responses to etomidate versus ketamine-thiopental sodium combination for anesthetic induction in CABG surgery patients with low ejection fraction (EF0.05). Muscle twitching was not observed in the two groups.Conclusion: Hemodynamic stability after administration of ketamine-thiopental sodium combination for induction of anesthesia in patients undergoing CABG surgery, with impaired ventricular function, supports the clinical impression that this combination is safe in CABG surgery patients with low EF.