Evaluation Of Deritis In Alcoholic And Non-Alcoholic Liver Diseases - A Case Control Study

摘要

Background: Oxidative stress and the influence of free radicals and their metabolites decrease the serum antioxidant status. They play a very important role in the pathogenesis of liver disease. The aim of the present study is to assess the Deritis in alcoholic and non-alcoholic liver disease patients in comparison to healthy controls and to evaluate its significance as a prognostic marker of liver disease. Methods: 100 cases were studied, of which 50 were normal healthy controls,10 were alcoholic hepatitis patients, 10 were non-alcoholic hepatitis patients, 10 were alcoholic cirrhosis patients and 20 were non-alcoholic cirrhosis patients. Serum AST and ALT levels were estimated in all subjects by using commercial kits from CPC diagnostics (Raichem USA). The readings were taken on a semiautoanalyser (STATFAX 3300). Statistical analysis was done by using the Student?s ?t? test. Results: The Deritis was significantly increased in patients with alcoholic hepatitis and cirrhosis as compared to non-alcoholic hepatitis and cirrhosis patients, respectively (P<0.05). Further, significantly elevated Deritis was observed in non-alcoholic hepatitis and cirrhosis patients as compared to healthy controls (P<0.001). Conclusion: The findings of the present study are consistent with previous studies, suggesting that hepatocyte damage causes leak of these enzymes into the circulation. This study concludes that Deritis is a dependable marker of alcoholic liver disease.