DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans

Gannavaram Sreenivas; B. V. Subba Raju; Ruchi Singh; Angamuthu Selvapandiyan; Robert Duncan; Dwijen Sarkar; Hira L. Nakhasi; Poonam Salotra

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DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans

机译：DNA多态性分析可区分引起卡拉-阿扎尔病的利什曼原虫和人类引起卡拉-阿扎尔后皮肤利什曼病的那些

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Leishmania donovani in India causes visceral infection (kala-azar) and dermal infection (post-kala-azar dermal leishmaniasis). We report here the identification of polymorphism in a well-defined genetic locus among the Leishmania parasites causing the visceral and dermal manifestations, in a comparison of 15 post-kala-azar dermal leishmaniasis and 12 kala-azar patient isolates.

机译：印度的 Leishmania donovani 引起内脏感染（黑热病）和皮肤感染（黑热病后的皮肤利什曼病）。我们在这里报告了在定义明确的遗传基因座中引起内脏和皮肤表现的利什曼原虫寄生虫中多态性的鉴定，比较了15名黑热病后皮肤利什曼病和12名黑热病患者隔离株。 展开▼

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《Journal of Clinical Microbiology》 |2004年第4期|共3页

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Gannavaram Sreenivas; B. V. Subba Raju; Ruchi Singh; Angamuthu Selvapandiyan; Robert Duncan; Dwijen Sarkar; Hira L. Nakhasi; Poonam Salotra;
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中图分类医学微生物学（病原细菌学、病原微生物学）;

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1. Development of a Species-Specific PCR Assay for Detection of Leishmania donovani in Clinical Samples from Patients with Kala-Azar and Post-Kala-Azar Dermal Leishmaniasis [J] . Poonam Salotra, G. Sreenivas, Gregory P. Pogue, Journal of Clinical Microbiology . 2001,第3期

机译：物种特异性PCR检测试剂盒的开发，用于检测来自卡拉-阿扎尔和卡拉-阿扎尔后皮肤利什曼病的患者临床样品中的利什曼原虫

2. Application of kDNA Minicircle PCR-RFLP to Characterize Leishmania donovani Clinical Isolates Obtained from Post-Kala-Azar Dermal Leishmaniasis in Eastern Nepal [J] . Ojesh Pokhrel, Keshav Rai, Narayan Raj Bhattarai, Canadian Journal of Infectious Diseases and Medical Microbiology: Journal Canadien des Maladies Infectieuses . 2019,第2期

机译：kDNA微型圆圈PCR-RFLP在表征尼泊尔东部卡拉-阿扎尔人皮肤利什曼病后获得的利什曼原虫临床分离株中的应用

3. IL-10- and TGF-beta-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania donovani infection in India. [J] . Saha S, Mondal S, Ravindran R, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第8期

机译：IL-10和TGF-β介导的在黑热病和黑热病后的皮肤利什曼病中的易感性：两性霉素B在控制印度利什曼原虫多诺万尼感染中的意义。

4. Morphological and Molecular Identification of Sri Lankan Leishmania Species Based on Kinetoplast Minicircle DNA and Cytochrome b Gene from Human Isolates [C] . L. Yatawara, S. Wickramasinghe, R.P.V.J. Rajapakse, International Congress of Parasitology . 2006

机译：基于Kinetoplast Minicircle DNA和来自人分离株的细胞色素B基因的Sri Lankan Leishmania物种的形态学和分子鉴定

5. Characterization of canine leishmaniasis in the United States: Pathogenesis, immunological responses, and transmission of an American isolate of Leishmania infantum. [D] . Rosypal, Alexa C. 2005

机译：美国犬利什曼病的特征：美国婴儿利什曼原虫分离株的发病机制，免疫应答和传播。

6. DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans [O] . Gannavaram Sreenivas, B. V. Subba Raju, Ruchi Singh, 2004

机译：DNA多态性分析可区分引起卡拉-阿扎尔病的利什曼原虫和人类造成卡拉-阿扎尔后皮肤利什曼病的那些

7. DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans [O] . Sreenivas, Gannavaram, Subba Raju, B. V., Singh, Ruchi, 2004

机译：DNA多态性分析可区分引起卡拉-阿扎尔病的利什曼原虫和人类造成卡拉-阿扎尔后皮肤利什曼病的那些

8. Cloning of 'Leishmania donovani' Genes Encoding Antigens Recognized during Human Visceral Leishmaniasis [R] . Sheppard, H. W., Dwyer, D. M. 1986

机译：编码人类内脏利什曼病中识别的抗原的'Leishmania donovani'基因的克隆

1. 二性霉素B脂质体成功治疗巴西利什曼原虫引起的皮肤利什曼病 [J] . Brown M ,Noursadeghi M ,Boyle J . 世界核心医学期刊文摘：皮肤病学分册 . 2005,第010期

2. 阿扎司琼联合甲氧氯普胺、维生素B6治疗急性白血病化疗引起的胃肠道反应 [J] . 王芳 ,魏伟 . 当代医学 . 2011,第017期

3. 用于PCR诊断皮肤利什曼病的存档吉氏染色涂片中利什曼原虫DNA的提取与扩增 [J] . 刘庆中 . 国外医学：寄生虫病分册 . 2002,第006期

4. 185用于PCR诊断皮肤利什曼病的存档吉氏染色涂片中利什曼原虫DNA的提取与扩增 [J] . . 国际医学寄生虫病杂志 . 2002,第006期

5. 抗利什曼原虫药物在利什曼病患者的单核细胞和体外培养的THP1细胞内引起γ-干扰素受体1的上调 [J] . 罗庆礼 ,沈继龙 . 国际医学寄生虫病杂志 . 2004,第005期

6. 一例由亲土性蔓状小孢子菌引起的驴皮肤癣菌病诊断报告 [C] . 殷珂 ,李华涛 . 2016中国驴业发展大会 . 2016

1. 定量由六种外感病邪所引起的皮肤变化的方法和使用该方法筛选改善皮肤状况的材料的方法 [P] . 中国专利： CN102203279A . 2011-09-28

2. 治疗由人类乳头瘤病毒引起的皮肤和粘膜疾病的外用中药 [P] . 中国专利： CN1840116A . 2006-10-04

3. Species-specific PCR assay for detection of Leishmania donovani in clinical samples of kala-azar and post kala-azar dermal leishmaniasis [P] . 外国专利： US6855522B2 . 2005-02-15

机译：用于检测黑热病和黑热病后皮肤利什曼病临床样品中的利什曼原虫的物种特异性PCR检测

4. Species-specific PCR assay for detection of Leishmania donovani in clinical samples of kala-azar and post kala-azar dermal leishmaniasis [P] . 外国专利： US2003162182A1 . 2003-08-28

机译：用于检测黑热病和黑热病后皮肤利什曼病临床样品中的利什曼原虫的物种特异性PCR检测

5. a composition comprising fractions or sub-fractions of leishmania promastigotes or amastigotes called fucose mannose ligand (fml) and saponin, a composition for preparing leishmaniasis transmission blocking vaccines in humans and animals comprising fractions or sub-fractions of leishmania promastigotes or amastigotes (fml) ) and saponin, use of the composition in the preparation of blocking vaccines to prevent the transmission of human or animal visceral leishmaniasis, use of the composition in the preparation of reagents consisting of administration of fractions or sub-fractions of leishmania promastigotes or amastigotes called fucose mannose ligand ( fml) and saponin [P] . 外国专利： BRPI0503187A . 2007-01-23

机译：包含利什曼原虫前鞭毛体或变形虫称为岩藻糖甘露糖配体（fml）和皂苷的级分或亚级分的组合物，用于制备人和动物中利什曼病传播阻断疫苗的组合物，包含利什曼原虫前体或变形虫（fml）的级分或亚级分皂苷，该组合物在制备预防人或动物内脏利什曼病传播的封闭疫苗中的用途，该组合物在制备利什曼原虫前鞭毛体或变形虫的级分或亚级分称为岩藻糖甘露糖的试剂中的用途配体（fml）和皂苷

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DNA Polymorphism Assay Distinguishes Isolates of Leishmania donovani That Cause Kala-Azar from Those That Cause Post-Kala-Azar Dermal Leishmaniasis in Humans

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