Membrane-Bound Neuregulin1 Type III Actively Promotes Schwann Cell Differentiation of Multipotent Progenitor Cells

Rainer Leimeroth; Christian Lobsiger; Agnes Lüssi; Verdon Taylor; Ueli Suter; Lukas Sommer

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Membrane-Bound Neuregulin1 Type III Actively Promotes Schwann Cell Differentiation of Multipotent Progenitor Cells

机译：膜结合的Neuregulin1 III型积极促进多能祖细胞的雪旺氏细胞分化。

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Manystepsofperipheralgliadevelopmentappeartoberegulatedbyneuregulin1(NRG1)signalingbuttheexactrolesofthedifferentNRG1isoformsintheseprocessesremaintobedetermined.Whileglialgrowthfactor2(GGF2),aNRG1typeIIisoform,isabletoinduceasatelliteglialfateinneuralcreststemcells,targetedmutationsinmicehaverevealedaprominentroleofNRG1typeIIIisoformsinsupportingsurvivalofSchwanncellsatearlydevelopmentalstages.Here,weinvestigatedtheroleofNRG1isoformsinthedifferentiationofSchwanncellsfromneuralcrest-derivedprogenitorcells.Inmultipotentcellsisolatedfromdorsalrootganglia,solubleNRG1isoformsdonotpromoteSchwanncellfeatures,whereassignalingbymembrane-associatedNRG1typeIIIinducestheexpressionoftheSchwanncellmarkersOct-6/SCIPandS100inneighboringcells,independentofsurvival.Thus,axon-boundNRG1mightactivelypromotebothSchwanncellsurvivalanddifferentiation.

机译：Manystepsofperipheralgliadevelopmentappeartoberegulatedbyneuregulin1（NRG1）signalingbuttheexactrolesofthedifferentNRG1isoformsintheseprocessesremaintobedetermined.Whileglialgrowthfactor2（GGF2），aNRG1typeIIisoform，isabletoinduceasatelliteglialfateinneuralcreststemcells，targetedmutationsinmicehaverevealedaprominentroleofNRG1typeIIIisoformsinsupportingsurvivalofSchwanncellsatearlydevelopmentalstages.Here，weinvestigatedtheroleofNRG1isoformsinthedifferentiationofSchwanncellsfromneuralcrest-derivedprogenitorcells.Inmultipotentcellsisolatedfromdorsalrootganglia，solubleNRG1isoformsdonotpromoteSchwanncellfeatures，whereassignalingbymembrane-associatedNRG1typeIIIinducestheexpressionoftheSchwanncellmarkersOct-6 / SCIPandS100inneighboringcells，independentofsurvival.Thus，轴突boundNRG1mightactivelypromotebothSchwanncellsurvivalanddifferentiation。

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《Developmental biology》 |2002年第2期|共页
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Rainer Leimeroth; Christian Lobsiger; Agnes Lüssi; Verdon Taylor; Ueli Suter; Lukas Sommer;
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1. Membrane-bound neuregulin1 type III actively promotes Schwann cell differentiation of multipotent progenitor cells [J] . Leimeroth R., Lobsiger C., Lussi A., Developmental biology . 2002,第2期

机译：膜结合neuregulin1 III型积极促进多能祖细胞的雪旺氏细胞分化
2. Activin promotes astrocytic differentiation of a multipotent neural stem cell line and an astrocyte progenitor cell line from murine central nervous system. [J] . Satoh M, Sugino H, Yoshida T Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2000,第3期

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7. Membrane-Bound Neuregulin1 Type III Actively Promotes Schwann Cell Differentiation of Multipotent Progenitor Cells [O] . Leimeroth Rainer, Lobsiger Christian, Lüssi Agnes, 2002

机译：膜结合的Neuregulin1 III型积极促进多能祖细胞的雪旺氏细胞分化。
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Membrane-Bound Neuregulin1 Type III Actively Promotes Schwann Cell Differentiation of Multipotent Progenitor Cells

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