COMPOSITION CONTAINING, AS ACTIVE INGREDIENT, CULTURE OF CHICKEN BONE MARROW-DERIVED OSTEOCHONDRAL PROGENITOR CELLS FOR PROMOTING OSTEOGENESIS OR INDUCING CHONDROGENIC DIFFERENTIATION

摘要

The present invention relates to a composition for promoting osteogenesis or inducing chondrogenic differentiation and, more specifically, to a composition containing, as an active ingredient, a culture of chicken bone marrow-derived osteochondral progenitor cells for promoting osteogenesis or inducing chondrogenic differentiation. Stem cells can be differentiated into osteocytes more effectively when the culture of chicken bone marrow-derived osteochondral progenitor cells is used mixed with an existing chemical material-based differentiation inducer used for induction of osteocytes according to the present invention compared when an osteogenic differentiation inducer is used alone, and starter chick bone marrow-derived osteochondral progenitor cells are high-quality osteochondral progenitor cells, which can be massively cultured due to high proliferating ability thereof and actively secrete various proteins for inducing the differentiation into chondrocytes, and thus the composition can provide a low-cost and high-efficiency chondrogenic differentiation inducer by using a culture of starter chick bone marrow-derived osteochondral progenitor cells without generation of a secondary ossification center. Accordingly, the present invention is expected to be usable as not only a therapeutic agent and adjuvant for bone injury diseases requiring formation or regeneration of new bones, such as osteoporosis, bone defect disease, Paget's disease, avascular necrosis of the femoral head, and osteoarthritis, but also a health functional food for bone health; and as not only a therapeutic agent and adjuvant for cartilage injury disease requiring formation or regeneration of new cartilage, such as degenerative arthritis, rheumatoid arthritis, fracture, muscle tissue injury, plantar fasciitis, tennis elbow, calcific tendinitis, fracture nonunion, or joint injury caused by external injury, but also a health functional food for joint health.