distal antenna and distal antenna-related function in the retinal determination network during eye development in Drosophila

摘要

emDrosophila/emeyespecificationoccursthroughtheactivityoftheretinaldetermination(RD)network,whichincludestheEyeless(Ey),Eyesabsent(Eya),Sineoculis(So)andDachshund(Dac)transcriptionfactors.Basedontheirabilitiestotransformantennalprecursorstowardsaneyefate,theemdistalantenna/em(emdan/em)andemdistalantenna-related/em(emdanr/em)genesencodetwonewRDfactors.DanandDanrareprobabletranscriptionfactorslocalizedinnucleiofeyeprecursorsanddifferentiatingeyetissue.Loss-of-functionsingleanddoubleemdan/danr/emmutantshavesmall,rougheyes,indicatingarequirementforwild-typeeyedevelopment.Inaddition,emdan/emandemdanr/emparticipateinthetranscriptionalhierarchythatcontrolsexpressionofRDgenes,andDanandDanrinteractphysicallyandgeneticallywithEyandDac.Eyespecificationculminatesindifferentiationofommatidiathroughtheactivitiesoftheproneuralgeneematonal(ato)/eminthefoundingR8photoreceptorandEgfrsignalinginadditionalphotoreceptors.DanrexpressionoverlapswithAtoduringR8specification,andDanandDanrregulateAtoexpressionandarerequiredfornormalR8inductionanddifferentiation.ThesedatademonstratearoleforDanandDanrineyedevelopmentandprovidealinkbetweeneyespecificationanddifferentiation./p/div