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首页> 外文期刊>The Journal of Experomental Medicine >CLASSIFICATION OF MYELOMA PROTEINS, BENCE JONES PROTEINS, AND MACROGLOBULINS INTO TWO GROUPS ON THE BASIS OF COMMON ANTIGENIC CHARACTERS
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CLASSIFICATION OF MYELOMA PROTEINS, BENCE JONES PROTEINS, AND MACROGLOBULINS INTO TWO GROUPS ON THE BASIS OF COMMON ANTIGENIC CHARACTERS

机译:根据常见的抗原特性将骨髓瘤蛋白,本杰氏蛋白和大球蛋白分为两类

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摘要

Antisera to normal 7S γ-globulin and to Bence Jones proteins permit the grouping of myeloma proteins (gamma and beta 2A types), Bence Jones proteins, and the Waldenstr?m type macroglobulins into two fundamental antigenic groups. The antigenic determinants responsible for this grouping are common to all these proteins which fall in the general category of immunoglobulins. Antisera to Bence Jones proteins were particularly useful for this classification since they failed to react with the proteins of the opposite group. These antisera also permit the grouping of normal 7S γ-globulin into two major types.The Bence Jones proteins from individual patients were found to correspond in antigenic group to that of the serum myeloma protein. Studies with antisera to 7S γ-globulin and to Bence Jones proteins indicated that the Bence Jones proteins were antigenically identical to a portion of the corresponding multiple myeloma protein molecules.
机译:对正常7Sγ球蛋白和Bence Jones蛋白的抗血清可将骨髓瘤蛋白(γ和β2A型),Bence Jones蛋白和Waldenstr?m型巨球蛋白分为两个基本抗原组。属于这种分组的抗原决定簇是所有属于免疫球蛋白一般类别的所有这些蛋白质所共有的。 Bence Jones蛋白质的抗血清对于这种分类特别有用,因为它们无法与另一组蛋白质反应。这些抗血清还可以将正常的7Sγ-球蛋白分为两种主要类型。发现个体患者的Bence Jones蛋白在抗原组上与血清骨髓瘤蛋白相对应。用针对7Sγ-球蛋白和Bence Jones蛋白的抗血清进行的研究表明,Bence Jones蛋白与相应的多发性骨髓瘤蛋白分子的一部分在抗原上相同。

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