A Golden Anniversary: Recognition That Rheumatoid Arthritis Sera Contain Autoantibodies Specific for Determinants on Native IgG Molecules

摘要

Fifty years ago, when this month’s Pillars of Immunology article appeared in The Journal of Experimental Medicine ([1][1]), the concept of systemic autoimmune disease did not exist, and systemic lupus erythematosus and rheumatoid arthritis were thought to be diseases of connective tissue or