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Qualitative and quantitative differences between common control banding tools for nanomaterials in workplaces

机译:工作场所纳米材料常用控制结合工具之间的定性和定量差异

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A number of control banding (CB) tools have been developed specifically for managing the risk of exposure to engineered nanomaterials. However, data on the methodological differences between common CB tools for nanomaterials in workplaces are rare. A comparative study with different CB tools, such as Nanosafer, Stoffenmanager-Nano, Nanotool, Precautionary Matrix, ECguidance, IVAM Guidance, ISO, and ANSES, was performed to investigate their qualitative and quantitative differences in real exposure scenarios. These tools were developed for different purposes, with different application domains, methodological principles, and criteria. Multi-criteria analysis showed that there was a diverse distribution of these eight CB tools across different evaluation indicators. The total evaluation scores for Nanotool, Stoffenmanager-Nano, and Nanosafer were higher than the other tools. Quantitative comparisons demonstrated that ANSES, ECguidance, and IVAM Guidance tools were better in terms of information availability. Nanotool, Stoffenmanager-Nano, and ECguidance were better in terms of the sensitivity of outputs to changes in exposure parameters. The Nanotool, ANSES, and ECguidance tools were better in terms of accuracy of hazard outcomes evaluated with toxicological data. The Stoffenmanager-Nano, Nanotool, and Nanosafer tools' exposure scores for seven scenarios had a good correlation with measurement data. The Nanotool and Stoffenmanager-Nano tools had much higher comprehensive advantages based on quantitative and qualitative assessment. More comparative studies evaluating different tools are required, using more types of nanomaterials in real exposure scenarios.
机译:已经专门开发了许多控制带(CB)工具来管理工程纳米材料的暴露风险。然而,关于工作场所中用于纳米材料的常用CB工具之间方法差异的数据很少。使用不同的CB工具(例如Nanosafer,Stoffenmanager-Nano,Nanotool,预防矩阵,EC指南,IVAM指南,ISO和ANSES)进行了比较研究,以研究它们在实际暴露场景下的质和量差异。这些工具是针对不同的目的而开发的,具有不同的应用领域,方法论原理和标准。多标准分析表明,这八个CB工具在不同的评估指标中分布不同。 Nanotool,Stoffenmanager-Nano和Nanosafer的总评估得分高于其他工具。定量比较表明,ANSES,ECguidance和IVAM Guidance工具在信息可用性方面更好。就输出对曝光参数变化的敏感性而言,Nanotool,Stoffenmanager-Nano和ECguided更好。用毒理学数据评估危害结果的准确性方面,Nanotool,ANSES和ECguidance工具更好。 Stoffenmanager-Nano,Nanotool和Nanosafer工具在七个场景中的暴露得分与测量数据具有良好的相关性。根据定量和定性评估,Nanotool和Stoffenmanager-Nano工具具有更高的综合优势。需要更多的评估研究来评估不同的工具,在实际曝光场景中使用更多类型的纳米材料。

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