Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pure and Pharmaceutical formulation by Using The Organic Reagent 2-5 dimethoxyaniline.

摘要

ABSTRACT A simple and sensitive spectrophotometric method for the determination of Chlorpromazine hydrochloride (CPZ) in pure form and in pharmaceutical dosage was developed. The method is based upon the oxidative coupling reaction between chlorpromazine hydrochloride and 2-5 dimethoxyaniline as a new organic reagent in the presence of oxidative agent NH4VO3. The reaction complete with a strong acidic medium to form a stable chromophore which absorbs at (717nm). The method showed a good lineari.