NEW CHROMOGENIC REAGENT FOR THE SPECTROPHOTOMETRIC DETERMINATION OF CHLORPROMAZINE HCL IN AQUEOUS SOLUTIONS AND PHARMACEUTICAL FORMULATIONS

摘要

Objective: Simple, rapid and accurate spectrophotometric method has been developed for the determination of Chlorpromazine HCl in pure and pharmaceutical formulations. Method: The method is based on the formation of violet color product as a result to interaction of mentioned drug with P-amino acetanilide as new chromogenic reagent in the presence of ferric chloride hexahydrate. The experiential conditions have been studied by UV-Vis spectrophotometric analysis. Results: The calibration curve was linear in the range 4-32ppm with a correlation coefficient of 0.9990 with a maximum absorbance at 590nm, while the limit of detection(L.O.D) was1.7ppm. The results compare favorable with those of official methods. Conclusion: The proposed method is simple and economical and can be used in the estimation of chlorpromazine HCl in bulk and pharmaceutical formulations.