Comparison of the modified Wayne

摘要

ABSTRACT Pyrazinamide (PZA) has an excellent sterilizing activity against semi dormant tubercle bacilli. When used in combination with Rifampicin the treatment has been shortened from 1year to 6 months. PZA is a pro drug which requires an acidic environment for its conversion into active form of Pyrazinoic acid. The in vitro drug susceptibility for PZA is not performed routinely as the culture medium should be acidified which in turn affects the growth of Mycobacterium tuberculosis. Currently, .