Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1

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Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1

机译：肉毒杆菌神经毒素A2亚型比A1亚型更快进入神经元细胞

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Botulinumneurotoxins(BoNTs),thecausativeagentofhumanbotulism,arethemostpotentnaturallyoccurringtoxinsknown.BoNT/A1,themoststudiedBoNT,isalsousedasanimportantbiopharmaceutical.Inthisstudy,thebiologicalactivityofBoNT/A1iscomparedtothatofBoNT/A2usingneuronalcellmodels.ThedataobtainedindicatefasterandincreasedintoxicationofneuronalcellsbyBoNT/A2thanBoNT/A1,andthatthemechanismunderlyingthisincreasedtoxicityisfasterandmoreefficientcellentrythatisindependentofgangliosidebinding.TheseresultshaveimportantimplicationsforthedevelopmentofnewBoNTbasedtherapeuticsandBoNTcountermeasures...

机译：Botulinumneurotoxins（BoNT中），thecausativeagentofhumanbotulism，arethemostpotentnaturallyoccurringtoxinsknown.BoNT / A1，themoststudiedBoNT，isalsousedasanimportantbiopharmaceutical.Inthisstudy，thebiologicalactivityofBoNT / A1iscomparedtothatofBoNT / A2usingneuronalcellmodels.ThedataobtainedindicatefasterandincreasedintoxicationofneuronalcellsbyBoNT / A2thanBoNT / A1，andthatthemechanismunderlyingthisincreasedtoxicityisfasterandmoreefficientcellentrythatisindependentofgangliosidebinding.TheseresultshaveimportantimplicationsforthedevelopmentofnewBoNTbasedtherapeuticsandBoNTcountermeasures ...

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《FEBS Letters》 |2010年第1期|共8页
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1. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1. [J] . Pier CL, Chen C, Tepp WH, FEBS letters. . 2011,第1期

机译：肉毒杆菌神经毒素A2型比A1型进入神经元细胞的速度更快。
2. Translocation domain of botulinum neurotoxin A subtype 2 potently induces entry into neuronal cells [J] . Microbiology and Immunology . 2020,第7期

机译：肉毒杆菌神经毒素的易位域A亚型2次级诱导进入神经元细胞
3. Characterization of Botulinum Neurotoxin A Subtypes 1 Through 5 by Investigation of Activities in Mice, in Neuronal Cell Cultures, and In Vitro [J] . Regina C. M. Whitemarsh, William H. Tepp, Marite Bradshaw, Infection and immunity . 2013,第10期

机译：通过研究小鼠，神经元细胞培养物中和体外的活性来表征肉毒杆菌神经毒素A亚型1至5
4. Use of Multiple Endoproteases in Sequential In-gel Digestions Improves Sequence Coverage of Botulinum Neurotoxins for Confident Subtyping [C] . Dongxia Wang, Jakub Baudys, Jon Rees, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用序贯内凝胶消化中的多种内瓣释放酶改善了肉毒杆菌神经毒素的序列覆盖，以为自信的亚型
5. Pharmacological properties and regulation of the rat neuronal nicotinic acetylcholine receptor alpha-3/beta-4 subtype stably expressed in HEK 293 cells. [D] . Meyer, Erin Linnea. 1998

机译：在HEK 293细胞中稳定表达的大鼠神经元烟碱型乙酰胆碱受体α-3/β-4亚型的药理特性和调控。
6. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1 [O] . Christina L. Pier, Chen Chen, William H. Tepp, -1

机译：肉毒杆菌神经毒素亚型A2比亚型A1更快地进入神经元细胞
7. Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1 [O] . Pier Christina L., Chen Chen, Tepp William H., 2011

机译：肉毒杆菌神经毒素A2亚型比A1亚型更快进入神经元细胞
8. Extraction and Inhibition of Enzymatic Activity of Botulinum Neurotoxins/A1, /A2, and /A3 by a Panel of Monoclonal Anti-BoNT/A Antibodies [R] . Kalb, S. R., Lou, J., Garcia-Rodriguez, C., 2009

机译：通过一组单克隆抗BoNT / a抗体提取和抑制肉毒杆菌神经毒素/ a1，/ a2和/ a3的酶活性

Botulinum neurotoxin subtype A2 enters neuronal cells faster than subtype A1

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