Dissolution Enhancement of Poorly Soluble Drug Aprepitant by Hot Melt Extrusion Method Using Hydrophilic Polymer: A Solid Dispersion Technique.

摘要

ABSTRACT The objective of this study was to develop a solid dispersion method for enhancing the aqueous solubility of aprepitant (BCS class II drug). In the present study a simplified definitive equivalent formulation is targeted by preparing a solid dispersion using hot melt extrusion. Model formulation isolated from a range of carrier-plastizer mixtures based on dissolution enhancements. Final choice was made with a combination of hydrophilic polymeric carrier hydroxyl propyl cellulose and a .