Formulation of Sustained Release Diltiazem Hydrochloride Matrix Tablets through Optimization and Their Evaluation

摘要

ABSTRACT The object of the present study is to develop sustained release system of the Diltiazem hydrochloride which is a calcium channel blocker widely used for its peripheral and vasodilator properties. Sustained release of the drug is devised from the matrix tablet dosage form. Matrix tablet is one of the least complicated approaches to sustain the release of drug candidates. Different grades of polymers HPMC viz HPMCK4M and HPMCK15M were selected to sustain the release of the drug up to 12 .